Wake-promoting agents: search for next generation modafinil: part I

Derek Dunn; Greg Hostetler; Mohamed Iqbal; Patricia Messina-McLaughlin; Alyssa Reiboldt; Yin Guo Lin; John Gruner; Edward R Bacon; Mark A Ator; Sankar Chatterjee

doi:10.1016/j.bmcl.2011.12.099

Wake-promoting agents: search for next generation modafinil: part I

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2312-4. doi: 10.1016/j.bmcl.2011.12.099. Epub 2011 Dec 29.

Authors

Derek Dunn¹, Greg Hostetler, Mohamed Iqbal, Patricia Messina-McLaughlin, Alyssa Reiboldt, Yin Guo Lin, John Gruner, Edward R Bacon, Mark A Ator, Sankar Chatterjee

Affiliation

¹ Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA.

PMID: 22264475
DOI: 10.1016/j.bmcl.2011.12.099

Abstract

In search of a next generation molecule to the novel wake promoting agent modafinil, a series of bi-phenyl derived wakefulness enhancing agents (in rat) was developed. From this work, compound 17 has been selected for additional studies.

MeSH terms

Animals
Area Under Curve
Benzhydryl Compounds / chemical synthesis*
Benzhydryl Compounds / pharmacokinetics
Benzhydryl Compounds / pharmacology
Biphenyl Compounds / chemical synthesis*
Biphenyl Compounds / pharmacokinetics
Biphenyl Compounds / pharmacology
Central Nervous System Stimulants / chemical synthesis*
Central Nervous System Stimulants / pharmacokinetics
Central Nervous System Stimulants / pharmacology
Electroencephalography
Injections, Intraperitoneal
Male
Modafinil
Motor Activity / drug effects
Rats
Rats, Sprague-Dawley
Sleep / drug effects
Stereoisomerism
Structure-Activity Relationship
Wakefulness / drug effects*
Wakefulness / physiology

Substances

Benzhydryl Compounds
Biphenyl Compounds
Central Nervous System Stimulants
Modafinil